Found 68 matching trials
A Study to Evaluate Safety and Pharmacokinetics of VX-659 in Healthy Subjects and in Adults With Cystic Fibrosis PHASE1 Evaluate the safety and tolerability of VX-659 in healthy subjects...
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Study of Cavosonstat (N91115) in Patients With CF Homozygous for the F508del-CFTR Mutation PHASE2 This will be a double-blind, randomized, placebo-controlled, parallel group...
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University of Alabama
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The Topic Trial - Study to Determine the Safety and Efficacy of Ivacaftor PHASE2 The study is a Phase 2 Study to establish the safety and efficacy of a drug...
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UAB Lung Health Center
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A Phase 2 Study to Evaluate Effects of VX-661/Ivacaftor on Lung and Extrapulmonary Systems in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation PHASE2 To evaluate the clinical mechanisms of action in lung and extrapulmonary sy...
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Multiple Locations
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A Study Evaluating the Safety and Efficacy of VX-659 Combination Therapy in Subjects With Cystic Fibrosis PHASE2 This is a Phase 2, randomized, double-blind, placebo- and tezacaftor/ivacaf...
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Yale New Haven Hospital
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Safety Study of Ivacaftor in Subjects With Cystic Fibrosis PHASE2 The purpose of this study was to evaluate the safety and tolerability of iv...
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University of Alabama Hospital
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Lumacaftor/Ivacaftor Combination Therapy in Subjects With CF Who Have an A455E CFTR Mutation PHASE2 This is a Phase 2, randomized, double-blind, placebo-controlled, multicente...
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University Medical Center, Utrecht, Department of Pulmonology and Tuberculosis
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A Study of Lumacaftor in Combination With Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older Who Are Homozygous for the F508del-CFTR Mutation PHASE3 The primary objective of the study was to evaluate the efficacy of lumacaft...
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Multiple Locations
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Phase 1, QT/QTC Interval Study in Healthy Subjects PHASE1 This study is designed to evaluate the effect of multiple doses of lumacaft...
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Multiple Locations
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Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia PHASE2 To evaluate the safety and efficacy of treatment with VX-371 with and witho...
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Multiple Locations
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